In molecular biology, the 'Wobble hypothesis' explains the flexibility in base pairing between the:
A. First base of the codon and the first base of the anticodon
B. Second base of the codon and the second base of the anticodon
C. Third base of the codon and the first base of the anticodon
D. DNA template and the newly synthesized mRNA
Answer: Option C
Solution (By JKSSB Mock Tests)
The Wobble hypothesis, proposed by Francis Crick, explains the degeneracy of the genetic code. It states that the base pairing rules (A-U, G-C) are strictly followed for the first two bases of the mRNA codon, but the third base of the codon (the 3' end) can form non-standard or 'wobble' base pairs with the first base of the tRNA anticodon (the 5' end). This allows a single tRNA molecule to recognize and bind to more than one synonymous codon.
No comments yet. Be the first to start the discussion!