The 'Philadelphia chromosome', associated with Chronic Myelogenous Leukemia (CML), is the result of a reciprocal translocation between chromosomes: MCQ with Answer and Explanation

The 'Philadelphia chromosome', associated with Chronic Myelogenous Leukemia (CML), is the result of a reciprocal translocation between chromosomes:
A. 9 and 22
B. 11 and 14
C. 14 and 21
D. 8 and 14
Answer: Option A
Solution (By JKSSB Mock Tests)
The Philadelphia chromosome is a specific genetic abnormality found in the bone marrow cells of most patients with Chronic Myelogenous Leukemia (CML). It is formed by a reciprocal translocation between the long arms of chromosome 9 and chromosome 22, denoted as t(9;22). This translocation fuses the BCR gene on chromosome 22 with the ABL1 gene on chromosome 9, creating a mutant BCR-ABL1 fusion protein with constitutive tyrosine kinase activity, driving uncontrolled cell division.

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The enzyme that catalyzes the conversion of glucose to glucose-6-phosphate is:
A. Phosphofructokinase
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Correct Answer: Option C


Explanation:
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Correct Answer: Option A


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Consider statements about ecology: 1. Producers form the first trophic level. 2. Energy flow in an ecosystem is unidirectional. 3. The pyramid of energy can be inverted. Which are correct?
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Correct Answer: Option C


Explanation:
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