The 'Philadelphia chromosome', associated with Chronic Myelogenous Leukemia (CML), is the result of a reciprocal translocation between chromosomes: MCQ with Answer and Explanation

The 'Philadelphia chromosome', associated with Chronic Myelogenous Leukemia (CML), is the result of a reciprocal translocation between chromosomes:
A. 8 and 14
B. 9 and 22
C. 14 and 21
D. 11 and 14
Answer: Option B
Solution (By JKSSB Mock Tests)
The Philadelphia chromosome is a specific genetic abnormality found in the bone marrow cells of most patients with Chronic Myelogenous Leukemia (CML). It is formed by a reciprocal translocation between the long arms of chromosome 9 and chromosome 22, denoted as t(9;22). This translocation fuses the BCR gene on chromosome 22 with the ABL1 gene on chromosome 9, creating a mutant BCR-ABL1 fusion protein with constitutive tyrosine kinase activity, driving uncontrolled cell division.

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Practice More Biology Questions

Question #1
In plant reproduction, the phenomenon where the pollen tube enters the ovule through the micropyle is called:
A. Mesogamy
B. Porogamy
C. Chalazogamy
D. Apogamy

Correct Answer: Option B


Explanation:
In angiosperms, the pollen tube must enter the ovule to deliver the male gametes to the embryo sac. The most common and typical pathway is through the micropyle (the small opening at the tip of the integuments), which is called porogamy. In some plants (like Casuarina, Juglans), the pollen tube enters through the chalaza (the base of the nucellus), which is called chalazogamy. Entry through the integuments is called mesogamy. Apogamy is the formation of a sporophyte without fertilization.

This question belongs to: Science Biology
Question #2
Consider the following statements about vitamins:
1. Vitamin K is essential for bone health.
2. Vitamin D deficiency can cause rickets.
3. Vitamin A is also known as tocopherol.
Which of the above is/are correct?
A. 1 and 3 only
B. 1 and 2 only
C. 1, 2, and 3
D. 2 and 3 only

Correct Answer: Option B


Explanation:
Vitamin K supports bone protein osteocalcin; D deficiency causes rickets. Vitamin A is retinol; vitamin E is tocopherol. So 3 is incorrect.

This question belongs to: Science Biology
Question #3
In the human digestive system, the 'Peyer's patches' are aggregated lymphoid nodules found primarily in the mucosa and submucosa of the:
A. Stomach
B. Esophagus
C. Ileum (small intestine)
D. Large intestine

Correct Answer: Option C


Explanation:
Peyer's patches are organized lymphoid follicles (aggregated lymphoid nodules) located in the mucosa and submucosa of the small intestine, most abundantly in the ileum (the distal part). They are a crucial component of the gut-associated lymphoid tissue (GALT) and play a vital role in monitoring intestinal bacteria populations, preventing the growth of pathogenic bacteria, and training the immune system to recognize antigens.

This question belongs to: Science Biology